Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review
강영훈, 변준호, 박봉욱,
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강영훈 ( Kang Young-Hoon ) - Gyeongsang National University School of Medicine Department of Oral and Maxillofacial Surgery
변준호 ( Byun June-Ho ) - Gyeongsang National University School of Medicine Department of Oral and Maxillofacial Surgery
박봉욱 ( Park Bong-Wook ) - Gyeongsang National University School of Medicine Department of Oral and Maxillofacial Surgery
KMID : 0355620140400050240
Abstract
Angiokeratoma is a benign cutaneous lesion of the capillaries, presenting as dilated vessels in the upper part of the dermis. Although this disorder is classified into various types and has been occasionally reported in the skin of the scrotum or extremities, the involvement of the oral cavity mucosa has been rarely reported. The present study reports a case of angiokeratoma circumscriptum in the buccal mucosa. The expression of vascular endothelial growth factor (VEGF) and both of its receptors (VEGFR-1 and VEGFR-2) was demonstrated by immunohistochemistry in the endothelial cells lining the dilated vessels. The expression of VEGFR-2 was higher than that of VEGFR-1 in the endothelial cells in the lesion, indicating an increased rate of endothelial cell proliferation within the lesion. Interestingly, some of the endothelial cells co-expressed VEGF and its two receptors. These results suggest that endothelial cells in the pathologically dilated vessels possess VEGF autocrine growth activity involved in vasculogenesis and maintenance in angiokeratoma lesions. To our knowledge, this is the second report published on isolated oral angiokeratoma confined to the buccal mucosa and the first case report on angiokeratoma circumscriptum involving the buccal mucosa.
키워드
Angiokeratoma circumscriptum; Buccal mucosa
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